Systemic sclerosis, also known as scleroderma, is a chronic autoimmune disease characterized by abnormal growth of connective tissue, which can lead to thickening and hardening of the skin and internal organs. The exact cause of systemic sclerosis is not well understood, but it is believed to result from a combination of genetic and environmental factors. Research in systemic sclerosis focuses on understanding the underlying mechanisms of the disease, developing better diagnostic tools, and identifying new treatments to improve outcomes for patients. Some areas of current research include studying the role of inflammation and immune dysfunction in the development of systemic sclerosis, identifying biomarkers for early detection and monitoring of the disease, and exploring new therapies aimed at targeting specific pathways involved in the disease process. Overall, research in systemic sclerosis aims to improve our understanding of the disease and develop more effective treatments to help improve the quality of life for individuals affected by this chronic and potentially disabling condition.